Review



simulsol sl 11w  (SEPPIC Inc)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    SEPPIC Inc simulsol sl 11w
    Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, <t>Simulsol,</t> and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.
    Simulsol Sl 11w, supplied by SEPPIC Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simulsol+sl+11w+sl-11w/simulsol/pmc10005542-37-0-7
    Average 90 stars, based on 1 article reviews
    simulsol sl 11w - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy"

    Article Title: Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy

    Journal: Nanomaterials

    doi: 10.3390/nano13050874

    Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, Simulsol, and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.
    Figure Legend Snippet: Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, Simulsol, and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.

    Techniques Used: Membrane, Labeling, Permeability, Impedance Spectroscopy

    EIS measurements for a tBLM treated with Simulsol at different concentrations. Time-resolved conductance (G m ) and specific capacitance (C m ) signals following the addition of ( A ) 4000 μM, ( B ) 2000 μM, and ( C ) 1000 μM Simulsol. Sequential arrows indicate compound addition and buffer washing. ( D – F ) Corresponding Bode plots showing phase minima shifts vs. frequency for the tBLM baseline (Baseline), after Simulsol addition (Treatment), and after buffer rinsing (Post-Wash). Note that 4000 μM Simulsol is above CMC and 2000 and 1000 μM Simulsol are below CMC.
    Figure Legend Snippet: EIS measurements for a tBLM treated with Simulsol at different concentrations. Time-resolved conductance (G m ) and specific capacitance (C m ) signals following the addition of ( A ) 4000 μM, ( B ) 2000 μM, and ( C ) 1000 μM Simulsol. Sequential arrows indicate compound addition and buffer washing. ( D – F ) Corresponding Bode plots showing phase minima shifts vs. frequency for the tBLM baseline (Baseline), after Simulsol addition (Treatment), and after buffer rinsing (Post-Wash). Note that 4000 μM Simulsol is above CMC and 2000 and 1000 μM Simulsol are below CMC.

    Techniques Used:

    Experimental summary of the final ( A ) G m and ( B ) C m shifts for the tBLM platform after treatment with 4000 μM TX-100, 4000 μM Simulsol, or 400 μM CTAB followed by buffer washing ( n = 3 independent experiments). In panel ( A ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were statistically significant ( P < 0.01) by one-way ANOVA. In panel ( B ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were also statistically significant ( P < 0.001). ( C ) Representative illustrations of the EIS results depicting the tBLM conditions after treatment with the highest test concentrations of TX-100, Simulsol, and CTAB (Treatment) and after buffer washing (Post-Wash).
    Figure Legend Snippet: Experimental summary of the final ( A ) G m and ( B ) C m shifts for the tBLM platform after treatment with 4000 μM TX-100, 4000 μM Simulsol, or 400 μM CTAB followed by buffer washing ( n = 3 independent experiments). In panel ( A ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were statistically significant ( P < 0.01) by one-way ANOVA. In panel ( B ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were also statistically significant ( P < 0.001). ( C ) Representative illustrations of the EIS results depicting the tBLM conditions after treatment with the highest test concentrations of TX-100, Simulsol, and CTAB (Treatment) and after buffer washing (Post-Wash).

    Techniques Used:

    Related Articles

    Concentration Assay:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Fluorescence:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Spectroscopy:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Molecular Weight:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Standard Deviation:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    QCM-D:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Comparison:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Membrane:

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements
    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).



    Similar Products

    simulsol sl 11w  (SEPPIC Inc)
    90
    SEPPIC Inc simulsol sl 11w
    Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, <t>Simulsol,</t> and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.
    Simulsol Sl 11w, supplied by SEPPIC Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simulsol+sl+11w+sl-11w/simulsol/pmc10005542-37-0-7
    Average 90 stars, based on 1 article reviews
    simulsol sl 11w - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier
    simulsol sl 11w sl-11w  (SEPPIC Inc)
    90
    SEPPIC Inc simulsol sl 11w sl-11w
    Critical micelle concentration (CMC) values for TX-100 and <t>SL-11W</t> based on fluorescence spectroscopy measurements. Peak wavelength of fluorescent probe (1-pyrenecarboxaldehyde) as a function of test compound concentration in PBS for ( A ) TX-100 and ( B ) SL-11W. The chemical structure of each detergent molecule is presented above the corresponding graph. The n values for TX-100 and SL-11W are 9–10 and 1–1.25, respectively, and were defined accordingly to be 9.5 and 1 for molecular weight calculations. Each data point represents the mean ± standard deviation from four technical replicates. The highest compound concentration at which there is no peak shift (relative to the baseline) is defined as the CMC value and indicated by shading.
    Simulsol Sl 11w Sl 11w, supplied by SEPPIC Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simulsol+sl+11w+sl-11w/simulsol+sl+11w+sl+11w/pmc08775805-99-14-21
    Average 90 stars, based on 1 article reviews
    simulsol sl 11w sl-11w - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, Simulsol, and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.

    Journal: Nanomaterials

    Article Title: Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy

    doi: 10.3390/nano13050874

    Figure Lengend Snippet: Overview of experimental strategy to evaluate membrane-disruptive properties of TX-100 detergent replacement candidates. ( A ) Commonly used biophysical methods for membrane-detergent interaction analysis require labeling and/or only provide indirect readouts of ionic permeability changes across lipid bilayers. ( B ) Proposed experimental strategy for TX-100 replacement testing based on electrochemical impedance spectroscopy (EIS). The molecular structures of the test compounds, TX-100, Simulsol, and CTAB are presented and defined bulk concentrations of each compound were individually added to the tethered bilayer lipid membrane (tBLM) platform. Time-resolved conductance (G m ) and capacitance (C m ) signals were monitored to evaluate how each compound disrupts the tBLM platform.

    Article Snippet: Simulsol SL 11W (Simulsol) was provided by Seppic Inc. (Fairfield, NJ).

    Techniques: Membrane, Labeling, Permeability, Impedance Spectroscopy

    EIS measurements for a tBLM treated with Simulsol at different concentrations. Time-resolved conductance (G m ) and specific capacitance (C m ) signals following the addition of ( A ) 4000 μM, ( B ) 2000 μM, and ( C ) 1000 μM Simulsol. Sequential arrows indicate compound addition and buffer washing. ( D – F ) Corresponding Bode plots showing phase minima shifts vs. frequency for the tBLM baseline (Baseline), after Simulsol addition (Treatment), and after buffer rinsing (Post-Wash). Note that 4000 μM Simulsol is above CMC and 2000 and 1000 μM Simulsol are below CMC.

    Journal: Nanomaterials

    Article Title: Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy

    doi: 10.3390/nano13050874

    Figure Lengend Snippet: EIS measurements for a tBLM treated with Simulsol at different concentrations. Time-resolved conductance (G m ) and specific capacitance (C m ) signals following the addition of ( A ) 4000 μM, ( B ) 2000 μM, and ( C ) 1000 μM Simulsol. Sequential arrows indicate compound addition and buffer washing. ( D – F ) Corresponding Bode plots showing phase minima shifts vs. frequency for the tBLM baseline (Baseline), after Simulsol addition (Treatment), and after buffer rinsing (Post-Wash). Note that 4000 μM Simulsol is above CMC and 2000 and 1000 μM Simulsol are below CMC.

    Article Snippet: Simulsol SL 11W (Simulsol) was provided by Seppic Inc. (Fairfield, NJ).

    Techniques:

    Experimental summary of the final ( A ) G m and ( B ) C m shifts for the tBLM platform after treatment with 4000 μM TX-100, 4000 μM Simulsol, or 400 μM CTAB followed by buffer washing ( n = 3 independent experiments). In panel ( A ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were statistically significant ( P < 0.01) by one-way ANOVA. In panel ( B ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were also statistically significant ( P < 0.001). ( C ) Representative illustrations of the EIS results depicting the tBLM conditions after treatment with the highest test concentrations of TX-100, Simulsol, and CTAB (Treatment) and after buffer washing (Post-Wash).

    Journal: Nanomaterials

    Article Title: Tethered Bilayer Lipid Membrane Platform for Screening Triton X-100 Detergent Replacements by Electrochemical Impedance Spectroscopy

    doi: 10.3390/nano13050874

    Figure Lengend Snippet: Experimental summary of the final ( A ) G m and ( B ) C m shifts for the tBLM platform after treatment with 4000 μM TX-100, 4000 μM Simulsol, or 400 μM CTAB followed by buffer washing ( n = 3 independent experiments). In panel ( A ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were statistically significant ( P < 0.01) by one-way ANOVA. In panel ( B ), the differences between TX-100 vs. Simulsol and TX-100 vs. CTAB were also statistically significant ( P < 0.001). ( C ) Representative illustrations of the EIS results depicting the tBLM conditions after treatment with the highest test concentrations of TX-100, Simulsol, and CTAB (Treatment) and after buffer washing (Post-Wash).

    Article Snippet: Simulsol SL 11W (Simulsol) was provided by Seppic Inc. (Fairfield, NJ).

    Techniques:

    Critical micelle concentration (CMC) values for TX-100 and SL-11W based on fluorescence spectroscopy measurements. Peak wavelength of fluorescent probe (1-pyrenecarboxaldehyde) as a function of test compound concentration in PBS for ( A ) TX-100 and ( B ) SL-11W. The chemical structure of each detergent molecule is presented above the corresponding graph. The n values for TX-100 and SL-11W are 9–10 and 1–1.25, respectively, and were defined accordingly to be 9.5 and 1 for molecular weight calculations. Each data point represents the mean ± standard deviation from four technical replicates. The highest compound concentration at which there is no peak shift (relative to the baseline) is defined as the CMC value and indicated by shading.

    Journal: International Journal of Molecular Sciences

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements

    doi: 10.3390/ijms23020869

    Figure Lengend Snippet: Critical micelle concentration (CMC) values for TX-100 and SL-11W based on fluorescence spectroscopy measurements. Peak wavelength of fluorescent probe (1-pyrenecarboxaldehyde) as a function of test compound concentration in PBS for ( A ) TX-100 and ( B ) SL-11W. The chemical structure of each detergent molecule is presented above the corresponding graph. The n values for TX-100 and SL-11W are 9–10 and 1–1.25, respectively, and were defined accordingly to be 9.5 and 1 for molecular weight calculations. Each data point represents the mean ± standard deviation from four technical replicates. The highest compound concentration at which there is no peak shift (relative to the baseline) is defined as the CMC value and indicated by shading.

    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Techniques: Concentration Assay, Fluorescence, Spectroscopy, Molecular Weight, Standard Deviation

    QCM-D tracking of the real-time interactions between SL-11W detergent and a DOPC SLB platform. Time-resolved ∆f (blue line with circles) and ∆D (red line with squares) shifts are presented as a function of time for SLB treatment with ( A ) 4000, ( B ) 2000, ( C ) 1000, ( D ) 500, ( E ) 250, or ( F ) 125 μM SL-11W. The baseline values at t = 0 min correspond to a DOPC SLB adlayer and arrows 1 and 2 denote the start of compound addition and buffer washing, respectively.

    Journal: International Journal of Molecular Sciences

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements

    doi: 10.3390/ijms23020869

    Figure Lengend Snippet: QCM-D tracking of the real-time interactions between SL-11W detergent and a DOPC SLB platform. Time-resolved ∆f (blue line with circles) and ∆D (red line with squares) shifts are presented as a function of time for SLB treatment with ( A ) 4000, ( B ) 2000, ( C ) 1000, ( D ) 500, ( E ) 250, or ( F ) 125 μM SL-11W. The baseline values at t = 0 min correspond to a DOPC SLB adlayer and arrows 1 and 2 denote the start of compound addition and buffer washing, respectively.

    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Techniques: QCM-D

    Comparison of QCM-D measurement responses for TX-100 and SL-11W interactions with SLB platform. Representative QCM-D measurement signals and corresponding data points that were used to define the baseline (arrow 1) and to calculate the maximum (arrow 2) and final (arrow 3) responses due to ( A ) TX-100 and ( B ) SL-11W detergent interactions with the SLB platform. Maximum ∆f (top panel) and ∆D (bottom panel) shifts corresponding to transient interaction processes occurring between ( C ) TX-100 or ( D ) SL-11W detergents and SLB platform. Final ∆f (top panel) and ∆D (bottom panel) shifts post-treatment corresponding to membrane-disruptive effects of ( E ) TX-100 and ( F ) SL-11W detergents on SLB platform after the last buffer washing step. The dashed lines denote the typical measurement values for a complete SLB adlayer. Shaded regions indicate concentration ranges in which the compounds are in the micellar state and the percentage values listed in ( E , F ) correspond to SLB removal fractions according to the Sauerbrey equation. Data are reported as mean ± standard deviation from four measurements.

    Journal: International Journal of Molecular Sciences

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements

    doi: 10.3390/ijms23020869

    Figure Lengend Snippet: Comparison of QCM-D measurement responses for TX-100 and SL-11W interactions with SLB platform. Representative QCM-D measurement signals and corresponding data points that were used to define the baseline (arrow 1) and to calculate the maximum (arrow 2) and final (arrow 3) responses due to ( A ) TX-100 and ( B ) SL-11W detergent interactions with the SLB platform. Maximum ∆f (top panel) and ∆D (bottom panel) shifts corresponding to transient interaction processes occurring between ( C ) TX-100 or ( D ) SL-11W detergents and SLB platform. Final ∆f (top panel) and ∆D (bottom panel) shifts post-treatment corresponding to membrane-disruptive effects of ( E ) TX-100 and ( F ) SL-11W detergents on SLB platform after the last buffer washing step. The dashed lines denote the typical measurement values for a complete SLB adlayer. Shaded regions indicate concentration ranges in which the compounds are in the micellar state and the percentage values listed in ( E , F ) correspond to SLB removal fractions according to the Sauerbrey equation. Data are reported as mean ± standard deviation from four measurements.

    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Techniques: Comparison, QCM-D, Membrane, Concentration Assay, Standard Deviation

    Schematic summary of TX-100 and SL-11W detergent interactions with DOCP SLB platform and proposed morphological changes based on QCM-D data. The DOPC phospholipid and TX-100 and SL-11W detergent molecules are represented by gray, orange, and magenta headgroup colors, respectively. Illustrative steps are shown for ( A ) TX-100 that induces rapid membrane solubilization starting from compound addition and resulting in complete lipid bilayer removal, and ( B ) SL-11W that induces membrane budding upon compound addition but does not cause membrane solubilization as indicated by final QCM-D measurement responses post-washing. Note that the spherical structures in AI and BI are intended to represent TX-100 and SL-11W detergent micelles, respectively, while the spherical structures in AII are intended to represent mixed micelles that form during membrane solubilization. In BII, membrane budding is driven by the intercalation of SL-11W molecules into the lipid bilayer, which causes local changes in spontaneous curvature.

    Journal: International Journal of Molecular Sciences

    Article Title: Supported Lipid Bilayer Platform for Characterizing the Membrane-Disruptive Behaviors of Triton X-100 and Potential Detergent Replacements

    doi: 10.3390/ijms23020869

    Figure Lengend Snippet: Schematic summary of TX-100 and SL-11W detergent interactions with DOCP SLB platform and proposed morphological changes based on QCM-D data. The DOPC phospholipid and TX-100 and SL-11W detergent molecules are represented by gray, orange, and magenta headgroup colors, respectively. Illustrative steps are shown for ( A ) TX-100 that induces rapid membrane solubilization starting from compound addition and resulting in complete lipid bilayer removal, and ( B ) SL-11W that induces membrane budding upon compound addition but does not cause membrane solubilization as indicated by final QCM-D measurement responses post-washing. Note that the spherical structures in AI and BI are intended to represent TX-100 and SL-11W detergent micelles, respectively, while the spherical structures in AII are intended to represent mixed micelles that form during membrane solubilization. In BII, membrane budding is driven by the intercalation of SL-11W molecules into the lipid bilayer, which causes local changes in spontaneous curvature.

    Article Snippet: Triton X-100 (TX-100) and 1-pyrenecarboxaldehyde were purchased from Sigma-Aldrich (St. Louis, MO, USA) and Simulsol SL 11W (SL-11W) was obtained from Seppic Inc. (Fairfield, NJ, USA).

    Techniques: QCM-D, Membrane